ZOYAGRA PLUS having the composition like Tadalafil + Dapoxetine is a combination of two medicines : Tadalafil and Dapoxetine, which treat premature ejaculation. Tadalafil is a phosphodiesterase type 5 (PDE 5) inhibitor which works by increasing blood flow to the penis during sexual stimulation and enables its erection following sexual stimulation. Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) which increases the level of serotonin in nerves to improve control over ejaculation and increase the time taken to ejaculate. ZOYAGRA PLUS is used in the treatment of premature ejaculation.